LIQUID CHROMATOGRAPHY; SCIENCE OR ART? When working with method development or trouble shooting of liquid chromatographic methods, one usually comes to a point where the method is not working as well as one would like it too. The action taken is often to try to solve a problem by testing more or less vague ideas. The reasoning, Maybe the problem can be solved if I change this or that parameter? One may ask; Is this the most rational approach to problem solving in liquid chromatography? To see an animated.

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